The Blonde Ambition makers have made a formidable enemy in Madonna.
Known for her bold onstage behaviour, looks like Madonna has once again put her foot in her mouth. The pop star delivered an explicit monologue about performing fellatio on men who vote for Hillary Clinton in next month's US presidential elections.
Madonna, who was at Amy Schumer's comedy set at Manhattan's Madison Square Garden in the New York, joked she gives "really good" oral sex.
"I'd better get off now because someone insanely funny is about to be on this stage, ladies and gentleman, one more thing before I introduce this genius of comedy. If you vote for Hillary Clinton, I will give you a b**wjob. I'm really good. I'm not a douche and I'm not a tool. I have eye contact and I do swallow," she said.
A fan posted the video on his Twitter page.
The 58-year-old Like A Virgin hitmaker finished off her monologue by introducing the funnywoman to her audience and admitting she wants to "one day" be able to do stand-up comedy like Schumer. Fans were no doubt surprised to see the pop star attempting to make people laugh.
The star singer's guest appearance came as a returned favour to Schumer after she opened up three of her dates in New York on her Rebel Heart world tour last year.